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In clinical trials, the three-drug combination cured hepatitis C in about 75% of patients who took telaprevir and about 67% of patients who took boceprevir.

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The Committee recommends a three-drug regimen because of the greater likelihood of enhanced effectiveness; however, use of a two-drug regimen would be preferred to discontinuing the regimen completely if tolerability is a concern.

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These STDs may cause mucosal ulcerations or tears or a higher concentration of inflammatory cells in the mucosa, which are targets for HIV infection.

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Late last year, hepatitis B experts from the American Association for the Study of Liver Disease (AASLD) tackled this question and reviewed recent studies that followed patients who stopped antivirals after losing HBeAg.

Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1.

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Extensive clinical experience, especially with ritonavir, has shown that CVP3A4-metabolized drugs such as methadone often need no dose adjustment.

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CAPRISA 004, a Phase IIb, double-blind, randomized, placebo-controlled study, assessed the effectiveness and the safety of a vaginal gel containing 1% tenofovir for the prevention of HIV infection in South African women.

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Taking these results together with findings from in-vitro transport experiments in MDCKII-transduced cells, we conclude that both ABCB1 and ABCG2 affect TDF transplacental kinetics.

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California team has had success treating recurrent HCV with DAAs.

Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.

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The most common mutation observed after efavirenz treatment is K103N, which is also observed with other NNRTIs.

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