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The FDA issued a Drug Safety Communication in October 2010 and will require a new Limitations of Use statement in the Indications and Usage section of the labels for these drugs.

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The following factors have been associated with an increased risk: Pre-existing renal dysfunction, dehydration, multiple cycles of zoledronic acid (the active ingredient contained in Reclast) or other bisphosphonates, concomitant use of nephrotoxic medicines and use of a shorter infusion time than what is recommended.

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Microcomputed tomography analysis demonstrated preservation of trabecular bone architecture in patients treated with ACLASTA compared to placebo.

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The zoledronic acid was administered every 3 to 4 weeks for 6 doses and then every 3 to 6 months to complete 5 years of treatment.

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The therapeutic response to Zoledronic Acid Injection was similar across demographic and disease-severity groups defined by gender, age, previous bisphosphonate use, and disease severity.

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Salter (December 15, 1924 to May 10, 2010) was a world renowned Orthopedic Surgeon, professor, author, scientist and was named one of the 10 most outstanding scientists of the past 80 years by the University of Toronto Faculty of Medicine.

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