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At 2 years, active treatment reduced overall mortality by 55% (from 45.

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While the principal mechanism of perindopril in blood pressure reduction is believed to be through the renin-angiotensin-aldosterone system, ACE inhibitors have some effect even in apparent low-renin hypertension.

Collaborative Low-dose Aspirin Study in Pregnancy--CLASP) did "not support routine prophylactic or therapeutic administration of antiplatelet therapy in pregnancy to all women at increased risk of preeclampsia or IUGR.

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Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing.

However, the evening valsartan dose preferentially lowered nocturnal BP compared with the morning dose, which translated into a 73% relative reduction in the proportion of patients with nondipper status.

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The opinions expressed in this article are his own and those of Dr Davis and are not necessarily those of the National Heart, Lung, and Blood Institute or the US Department of Health and Human Services, the editors, or the American Heart Association.

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Use of Combination Antihypertensive Therapy Initiation in Older Americans without Prevalent Cardiovascular Disease.

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CONVINCE indicates Controlled Onset Verapamil Investigation of Cardiovascular End Points; ELSA, European Lacidipine Study on Atherosclerosis; HAPPHY, Heart Attack Primary Prevention in Hypertension; INVEST, International Verapamil-Trandolapril Study; MRC, Medical Research Council; NORDIL, Nordic Diltiazem Study; STOP-2, Swedish Trial in Old Patients With Hypertension; and UKPDS, UK Prospective Diabetes Study.

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